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Principal Scientist I, In Vivo Pharmacology (Echocardiography) – CVM

REQ-10052464
5月 23, 2025
USA

摘要

We are seeking a highly motivated scientist with expertise in echocardiography to join our in vivo pharmacology team in the Cardiovascular and Metabolic (CVM) Disease Area at the Novartis BioMedical Research (BR) facility in Cambridge, MA. Cardiometabolic disease is the leading cause of death globally, claiming approximately 17.9 million lives annually. Our team is committed to developing innovative medicines to address this critical health issue. We design, develop, validate, and utilize pharmacological tools to assess the efficacy and safety of new cardiometabolic drug candidates.
As an experienced and skilled lab-based echocardiographer, you will work both independently and collaboratively in an interdisciplinary setting to conduct experiments in preclinical models of cardiovascular disease. You will perform multi-mode echocardiography, including strain by speckle tracking and Doppler imaging, to assess heart systolic and diastolic function. You will collect, analyze, and interpret echo images, and report cardiac structural and functional data in both written study reports and team meetings. You will support drug discovery for heart failure and arrhythmia therapeutics by participating in pharmacodynamic/pharmacokinetic (PK/PD) and efficacy studies, while expanding your knowledge in the field of non-invasive imaging.
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This position will be located at Cambridge, MA and will not have the ability to be located remotely.

About the Role

Key Responsibilities:

  • Independently design, execute, analyze, and document in vivo echocardiographic experiments in heart failure and/or arrhythmia animal models.
  • Actively mentor, train, and support the career development of direct reports, matrix direct reports, or junior associates.
  • Leverage extensive, current knowledge of heart failure and arrhythmia indications to initiate, influence and/or drive projects.
  • Identify scientific and technical trends in the field that influence project outcomes.
  • Utilize comprehensive knowledge of project and drug discovery processes to formulate and address key scientific and technical questions.
  • Establish new imaging techniques and approaches to support heart failure or arrhythmia studies.
  • Adhere to good laboratory practices, including meticulous data recording and documentation.
  • Contribute to drug discovery projects by conducting PK/PD studies.
  • Work collaboratively and efficiently within a matrixed environment.

Role Requirements:

  • Master's Degree plus 3 years of experience or recently completed PhD in Pharmacology or related life sciences preferred.
  • Experience in conducting echocardiography in preclinical animal models of heart failure and arrhythmia.  Experience in MRI is a plus.
  • Proven expertise in experimental design and execution.
  • Experience in working with a multidisciplinary team of scientists.
  • Sound understanding of statistics and experience with common statistical software for biomedical research.
  • Strong written, oral and record keeping skills.

Our Expectations:

  • An ability to work both independently and as part of a team
  • Flexibility and aptitude for learning, with a passion to drive groundbreaking science

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $103,600 and $192,400/year; however, while salary ranges are effective from 1/1/25 through 12/31/25, fluctuations in the job market may necessitate adjustments to pay ranges during this period.  Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. 

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? http://www.novartis.com/about/strategy/people-and-culture

Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: http://talentnetwork.novartis.com/network

Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: http://www.novartis.com/careers/benefits-rewards

Biomedical Research
Pharma Research
USA
Massachusetts
Cambridge (USA)
Research & Development
Full time
Regular
No
A female Novartis scientist wearing a white lab coat and glasses, smiles in front of laboratory equipment.
REQ-10052464

Principal Scientist I, In Vivo Pharmacology (Echocardiography) – CVM

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